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Ambroxol and clenbuterol are two drugs with potential pharmacological synergy. The objective of this study was to compare the apparent bioavailabilities at steady-state of these two compounds administered alone or in combination (CHF-023). Nine healthy male volunteers participated in the study. Potentiometric detection of clenbuterol, ambroxol and bromhexine in marketed pharmaceuticals was described in six isocratic HPLC systems. Ambroxol is a medication indicated for airway secretion clearance therapy. Generic Name Ambroxol DrugBank Accession Number DB06742 Background. Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. Ambroxol and bromhexine containing medicinal products INN: ambroxol and bromhexine Procedure number: EMEA/H/A-31/1397 Note Assessment report as adopted by the PRAC and considered by the CMDh with all information of a commercially confidential nature deleted. EMA/PRAC/800767/2015 Page 2 Table of contents 1. In this study, we investigated the pharmacokinetics of ambroxol and clenbuterol after oral administration of single dosage and multiple dosages of Ambroxol and Clenbuterol Tablets in healthy Chinese adults, based on which to provide the reference information for the clinical application of the medication. PMCID: PMC4694390 Abstract Objective: To investigate the pharmacokinetics of Ambroxol and Clenbuterol Tablets in Chinese healthy volunteers after a single or multiple dosages oral administration. Methods: A total of 9 healthy adult subjects were given Ambroxol and Clenbuterol Tablets in a single dosage or multiple dosages respectively
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